Model Customization

MingCelerKnock-In

Knock-in

Knock-in mice (KI) are genetically engineered models in which an exogenous functional gene is precisely inserted into a specific genomic locus via homologous recombination, enabling stable and persistent expression within cells. Mingxun Biotech employs the TurboMice™ tetraploid complementation technique to efficiently generate knock-in mice. MingCeler Biotech offers customized precision Rosa26 KI and H11 KI mouse models—both recognized as "safe harbor" sites. These ensure stable, widespread, and predictable expression of the inserted gene across various tissues, without compromising the health of the mice. Using our advanced platform, homozygous KI mice can be generated directly from engineered cells in a single step, with a model development cycle as short as three months, significantly accelerating your research progress.

TurboMice™ Deliverables

End-to-End Services
Vector Design
ESC Editing
Tetraploid Complementation
Experiment-Ready Mice.

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Customized Genetic Models with Guaranteed Homozygosity—No Breeding Required

Guarantee

Mingceler provides the industry's most robust guarantee: successful generation of genetically engineered knockout mice. Should we fail to deliver animals with the specified genotype, the client’s service fee will be fully refunded*.

*Exclusions apply for genetic modifications that severely compromise viability, morbidity, or fertility due to intrinsic biological constraints.

Given the inherent complexity of biological systems, genetic modifications may not yield anticipated phenotypic outcomes. Mingceler’s guarantee strictly pertains to the development of animals possessing the genotype specified in the contract, with an accuracy of 100% at the DNA level, not the particular biological outcome, such as:

Gene transcription levels
Protein/RNA functionality
Organism-level biological phenotype

Online Quotation

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KO CKO KI CKI Humanize PM Transgenic IVF other
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5 10 20 other
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