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MingCelerHumanization

Humanization

Humanized mice are genetically engineered models created by introducing human genes, cells, or tissues into mice to simulate human disease mechanisms and physiological processes.
MingCeler Biotech utilizes the TurboMice™ tetraploid complementation technique to generate humanized mouse models directly from edited cells in a single step. The TurboMice™ platform supports a wide range of humanization strategies, including codon, domain, exon, and coding sequence humanization, as well as multi-gene locus and whole-gene humanization editing.
Humanization

Our advantages

  • 01
    Rapid Production Without Breeding: Achieve homozygous F0 mice in 2 months.
  • 02
    Unmatched Capacity for Complex Models: 100 kb knock-ins, Mb-range deletions, Multi-target gene editing.
  • 03
    Cryopreserved ES Cell Bank of gene targeted mice – Zero Genetic Drift, 3R-Compliant Archiving, Free 2-year cryostorage of validated ES clones.
  • 04
    "Clone Factory" Mass Production: Unlimited expansion of gene-edited ES cells for mass production of the homozygous/multi gene edited mice.

TurboMice™ Deliverables

  • End-to-End Services
  • Vector Design 
  • ESC Editing
  • Tetraploid Complementation 
  • Experiment-Ready Mice.
 

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Customized Genetic Models with Guaranteed Homozygosity—No Breeding Required
TurboMice™ Deliverables
  • TurboMice™ stands at the forefront of next-generation mouse model creation, providing unmatched efficiency and precision in genetic engineering. By harnessing optimized tetraploid complementation technology, we offer researchers the ability to generate complex mouse models faster and more accurately than ever before.
    TurboMice™ stands at the forefront of next-generation mouse model creation, providing unmatched efficiency and precision in genetic engineering. By harnessing optimized tetraploid complementation technology, we offer researchers the ability to generate complex mouse models faster and more accurately than ever before.
  • With the ability to simultaneously edit multiple genes, TurboMice™ eliminates traditional bottlenecks like breeding and screening, dramatically reducing model development time. This revolutionary approach enables accelerated research and opens the door to more advanced and reliable scientific discoveries.
    With the ability to simultaneously edit multiple genes, TurboMice™ eliminates traditional bottlenecks like breeding and screening, dramatically reducing model development time. This revolutionary approach enables accelerated research and opens the door to more advanced and reliable scientific discoveries.

Guarantee

Mingceler provides the industry's most robust guarantee: successful generation of genetically engineered knockout mice. Should we fail to deliver animals with the specified genotype, the client’s service fee will be fully refunded*.

*Exclusions apply for genetic modifications that severely compromise viability, morbidity, or fertility due to intrinsic biological constraints.

Given the inherent complexity of biological systems, genetic modifications may not yield anticipated phenotypic outcomes. Mingceler’s guarantee strictly pertains to the development of animals possessing the genotype specified in the contract, with an accuracy of 100% at the DNA level, not the particular biological outcome, such as:

  • Gene transcription levels
  • Protein/RNA functionality
  • Organism-level biological phenotype

Online Quotation

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Alternatively, call us at 400-8388-113 or reach technical support at 18126776342 (also available on WeChat).