FAQMingCeler

qHow much do mouse model generation projects cost?

a

•Request a free quote.
•Mingceler specializes in customized mouse model generation services, with project pricing determined by the complexity of the project, materials supplied by the customer, and specified deliverables.
•We provide a complimentary, no-obligation project design and proposal tailored to your specific requirements.

qHow long does it take to generate a mouse model?

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• Mingceler delivers novel mouse models in an average of 24 weeks.
• From scratch, we deliver experiment-ready homozygous target mice (F0) in as fast as 12 weeks.
• Please see our timelines for more information.
Mingceler continuously optimizes project timelines through Lean management principles—stabilizing, standardizing, and refining each process. Our proprietary TurboMice™ technology exemplifies this refinement, enabling rapid generation of genetically engineered mice with industry-leading efficiency while significantly enhancing animal welfare.

qHow soon can Mingceler start your project?

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•Zero project backlog — Mingceler’s streamlined pipeline enables immediate project initiation. •Execution commences within 24 hours of receiving signed contract and purchase order.

qWhat technology does Mingceler use?

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•Mingceler utilizes proprietary Turbomice™ technology for embryonic stem (ES) cell gene targeting, significantly enhancing 3R compliance and accelerating development timelines for genetically engineered mouse models.
•Developed through systematic optimization of tetraploid complementation and stem cell precision editing, TurboMice™ enables targeted genomic modifications at virtually any locus within 3–5 months.
•We also use various technologies to validate and phenotype your mouse lines e.g. RT-qPCR, Western Blot, ELISA and flow cytometry.

qCan Mingceler breed my mice?

a

Mingceler delivers end-to-end breeding solutions for genetically engineered mouse models—propagating Mingceler-generated or imported lines, scaling colonies to yield defined cohorts, executing Flp/Cre crossbreeding, and operating through AAALAC-accredited facilities in Australia/USA.

qWhat genetic backgrounds are offered?

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Mingceler offers gene targeting on the following backgrounds:
•C57BL/6N
•C57BL/6J
•BALB/c
•ICR
Less common strains as required

qDoes Mingceler offer partial mouse model projects?

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Mingceler recommends end-to-end services from project design to homozygous mouse delivery, ensuring integrated QC for ES cell targeting and germline transmission. When full model generation is unfeasible, we provide modular solutions:
• Gene targeting vector construction
• Targeted ES cell derivation (using Mingceler or client-supplied vectors)
• TurboMice™-based mouse line generation from client/repository ES cells
• Experimental cohort breeding (Mingceler or external models)
• Validation and phenotyping services (all models)

qDoes Mingceler sell off-the-shelf models?

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• QuickMice™ nuNPG Mice
• QuickMice™ HPV Mice
• QuickMice™ hHLA Mice
• QuickMice™ LMNA Mice
• QuickMice™ hPSCK9 Mice
• QuickMice™ hTIGIT Mice
• QuickMice™ hACE2 Mice

qWhat kind of humanised models does Mingceler generate?

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Mingceler engineers genomic humanization mouse models through precise orthologous gene replacement, including:
•humanising point mutations.
•humanising domains, such as extracellular domains.
•humanising multi-gene loci.
We recommend the TurboMiceTM technology for genomic humanisations (10-30 kb).

qHow much for a project assessment?

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•Free initial design proposal with zero obligations.
•Request a free quote!

qWho owns the mouse lP? Do l need a licence from Mingceler?

a

Service Model
•Mingceler operates under a fee-for-service framework for all model generation projects.
IP Ownership
•All intellectual property rights pertaining to custom mouse models, including derived organs, tissues, cells, and biological materials, are the sole and exclusive property of Mingceler.
Third-Party Transfer Prohibition
•Mingceler reserves the right to retain, utilize, or commercialize client project materials (e.g., targeting vectors, ES cells, mouse lines) without prior consent.
Licensing Requirement
•Clients must obtain a written license from Mingceler for any use of the models or derivatives, including but not limited to:
1)Commercialization
2)Distribution to third parties
3)Publication involving model data

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